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KMID : 0361019950380030384
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Korean Journal of Otolaryngology - Head and Neck Surgery
1995 Volume.38 No. 3 p.384 ~ p.389
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Changes in Horseradish Peroxidase permeability of Rat Nasal Mucosa by Selective Stimulation of Substance p Innervation with Capsaicin
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김남주
전시영/홍순관/황의기/김충섭/김진평
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Abstract
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To investigate the physiological role of the substance P innervation (SPI) in the nasal mucosa from inhaled irritant macromolecules, SPI was selectively stimulated by capsaicin and the degree of horseradish peroxidase (HRP) permeability across
the
epithelium of the nasal mucosa of the rat was evaluated by the enzyme immunoassay, or the electron microscopic histochemistry.
The serum level of HRP were reduced significantly in capsaicin administered rats along the time course with quantitative analysis. Control rats showed heavy permeation of HRP across the epithelium, but capsaicin administered rat showed weak
permeation
of HRP across the epithelium in histochemical electron microscopy. The epithelial lining and its tight junctions were left intact as judged by the electron microscopy. IN conclusion, selective stimulation of SPI of the rat nasal mucosa with
capsaicin
decreased the epithelial absorption permeability to HRP without compromising the epithelial integrity.
These findings imply that the major role of capsaicin sensitive nerve in the nasal mucosa is to protect the permeation of inhaled irritant macromolecules.
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KEYWORD
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